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The narcotic antagonists, naloxone or nalmefene, are distinct antidotes for opioid overdose. Opioid antagonists shouldn't be administered within the absence of clinically considerable respiratory or circulatory depression secondary to ROXICODONE (oxycodone hydrochloride) ® overdose. If wanted the appropriate dose of naloxone hydrochloride or nalme

Actual physical dependence and tolerance are not unusual throughout Continual opioid therapy. Substantial tolerance mustn't happen in the majority of clients taken care of with the bottom doses of oxycodone. It ought to be predicted, on the other hand, that a fraction of sufferers will acquire some diploma of tolerance and call for progressively bi